Metformin

Studies have found that metformin can help with weight loss, especially for those who are overweight and at risk for diabetes.

About Metformin

Overview

Metformin is often the first medication recommended for those with type 2 diabetes, as it helps improve blood sugar control by increasing insulin sensitivity. Research has shown that many individuals taking metformin also experience weight loss, making it beneficial for those who are overweight and at risk for diabetes. While the FDA has not approved metformin for weight loss, some doctors may prescribe it for this purpose in an off-label use. Using metformin for weight loss can help prevent diabetes in those who are at risk. Overall, metformin can be a useful tool in managing both diabetes and weight.

Doctors are not completely certain about the mechanism of metformin in aiding weight loss, but they believe it involves a variety of factors. One significant way it helps is by decreasing appetite. This is achieved by boosting levels of hormones that reduce hunger. Metformin also decreases glucose production by the liver, potentially decreasing the need for insulin. Additionally, it enhances insulin sensitivity, allowing the body to utilize insulin more effectively. Moreover, it alters the gut microbiome, which aids in the digestion of food.

Metformin may help you lose a modest amount of weight and prevent weight gain, but it is not a miracle weight loss pill like some other diabetes medications. Drugs like semaglutide and tirzepatide have resulted in more significant weight loss than metformin. In a study with over 3,000 participants, those taking metformin lost an average of 5.5 pounds, with one-third losing at least 5% of their body weight after a year and up to 6.2% over 15 years. While metformin may aid you in your health goals, it should not replace a healthy diet and regular exercise.

Advantages

Researchers have indicated that metformin, a medication commonly used to treat diabetes, may stimulate the body’s production of a molecule that is typically generated post-intense physical activity, resulting in weight loss benefits. This particular molecule is recognized for its appetite-suppressing properties. It is suggested by experts that metformin can facilitate moderate weight loss through various mechanisms, with a particular emphasis on the importance of regular exercise.

Pros

Metformin improves

Insulin sensitivity
Reduces glucose levels
Aids in weight loss
Balances testosterone
Improves fertility

Cons

Mild side effects of metformin may include nausea, stomach upset, or diarrhea
Rare but more serious side effects can include severe allergic reactions
Another rare side effect is lactic acidosis, which is a buildup of lactic acid in the bloodstream
People with significant kidney disease are at higher risk for lactic acidosis and may not be prescribed metformin
Overall, serious side effects of metformin are uncommon

What to Expect

Being overweight is a complex condition that often requires multiple therapies, including dietary changes, exercise, medications, and behavior modification programs.

Overweight is defined by a BMI of 25 to 29.9, while obesity is categorized by a BMI of 30 or higher.

Metformin may be prescribed by healthcare providers for overweight individuals after thorough consultation.

In a research study comprising non-diabetic obese individuals, participants administered with metformin experienced an average weight loss of 5.8 kg (equivalent to approximately 13 pounds), whereas the group receiving a placebo exhibited weight gain.

Safety Profile

The safety profile of metformin is favorable. Furthermore, researchers are currently exploring the potential benefits of metformin in reducing the incidence of cancer in individuals with type 2 diabetes, particularly breast, colon, and prostate cancers.

Additionally, there is evidence suggesting that metformin may decrease the risks of dementia and stroke, with studies showing reduced cognitive decline, lower rates of dementia, and stroke in diabetic patients taking metformin compared to those not taking it.

Moreover, preliminary research indicates that metformin may have anti-aging properties, potentially preventing age-related diseases and extending lifespan by enhancing insulin sensitivity, antioxidant effects, and improving cardiovascular health.

Metformin is contraindicated in people that have heart failure, kidney or liver problems, severe infections or severe problems with circulation or breathing difficulties.

Cost

The benefit of Metformin for weight loss is it is very low cost in comparison to other weight loss drugs.

The price of metformin oral tablet 500 mg is approximately $11 for a 30-tablet supply, contingent upon the specific pharmacy from which it is purchased.

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