Metformin is often the first medication recommended for those with type 2 diabetes, as it helps improve blood sugar control by increasing insulin sensitivity. Research has shown that many individuals taking metformin also experience weight loss, making it beneficial for those who are overweight and at risk for diabetes. While the FDA has not approved metformin for weight loss, some doctors may prescribe it for this purpose in an off-label use. Using metformin for weight loss can help prevent diabetes in those who are at risk. Overall, metformin can be a useful tool in managing both diabetes and weight.

 

Doctors are not completely certain about the mechanism of metformin in aiding weight loss, but they believe it involves a variety of factors. One significant way it helps is by decreasing appetite. This is achieved by boosting levels of hormones that reduce hunger. Metformin also decreases glucose production by the liver, potentially decreasing the need for insulin. Additionally, it enhances insulin sensitivity, allowing the body to utilize insulin more effectively. Moreover, it alters the gut microbiome, which aids in the digestion of food.

 

Metformin may help you lose a modest amount of weight and prevent weight gain, but it is not a miracle weight loss pill like some other diabetes medications. Drugs like semaglutide and tirzepatide have resulted in more significant weight loss than metformin. In a study with over 3,000 participants, those taking metformin lost an average of 5.5 pounds, with one-third losing at least 5% of their body weight after a year and up to 6.2% over 15 years. While metformin may aid you in your health goals, it should not replace a healthy diet and regular exercise.