GLP-1 Oral

Semaglutide is available in tablet or sublingual form as an oral option for weight loss without the need for injections.

About GLP-1 Oral

Overview

Ingest Semaglutide orally for weight loss without injections. Semaglutide, the active pharmaceutical compound, has demonstrated efficacy in facilitating weight loss and its maintenance when used in conjunction with diet and exercise regimens. Its mechanism of action involves stimulating insulin secretion, reducing glucagon release, and influencing brain regions responsible for appetite and food consumption regulation.

Advantages

A research review conducted in 2021 examined multiple clinical studies on GLP-1s to determine the efficacy of oral semaglutide compared to the injectable version for weight loss. The review concluded that once-a-day oral semaglutide is equally or more effective than injectable semaglutide in promoting weight loss and reducing A1C levels in individuals with diabetes.

This review also highlighted a distinguishing feature of oral tablets, which may offer similar or better efficacy and tolerability compared to most injectable GLP-1s.

It is important to note, however, that not all semaglutides are approved by the FDA for weight loss purposes. As these medications are relatively new, further research is necessary to make a direct comparison between oral and injectable semaglutides.

It is worth mentioning that the research primarily focused on individuals with diabetes who were receiving insulin, potentially impacting the data.

Therefore, additional studies are required to thoroughly investigate this area of inquiry.

Pros

Oral GLP-1 tablets:

Do not necessitate the utilization of needles
Are generally administered on a daily basis
As effective as injectable GLP-1 receptor agonist

Cons

May lead to adverse reactions such as nausea, vomiting, and abdominal discomfort
It is advised to ingest them on an empty stomach upon waking in the morning, and to refrain from eating for the subsequent 30 minutes.

What to Expect

Being overweight is a complex condition that often requires multiple therapies, including dietary changes, exercise, medications, and behavior modification programs.

Overweight is defined by a BMI of 25 to 29.9, while obesity is categorized by a BMI of 30 or higher.

Semaglutide oral medication may be prescribed by healthcare providers for overweight individuals after thorough consultation.

Individuals with obesity or overweight who are eligible for GLP-1 oral medication will take daily.

Weight loss success varies depending on individual factors, but most clients typically lose around 5% of their initial bodyweight. Some clients may even experience weight loss of up to 10% over a 12-week period. For a 300-pound person, this could mean shedding around 20 to 30 pounds.

However, results can vary greatly from person to person, and successful clients often put in effort to make sustainable diet and lifestyle changes.

Once goal weight is reached, a maintenance dose will be considered or alternative oral medications.

Safety Profile

Overall, GLP-1 injectable drugs are considered safe, but there are rare complications that can arise.

These complications include pancreatitis, which can cause abdominal pain.

Another potential side effect is gastroparesis, which slows or stops the movement of food from the stomach. Additionally, bowel obstruction can occur, preventing food from passing through the intestines.

Lastly, gallstone attacks and bile duct blockage are less common but more serious side effects of GLP-1 agonists.

While most side effects of GLP-1 drugs are not deemed serious, individuals should promptly seek medical attention if they experience:

Severe vomiting and diarrhea
Intense abdominal pain or tenderness
Inability to pass gas or move bowels
Jaundice (yellowing of the skin).

Furthermore, patients should inform their healthcare provider if they are scheduled for surgery or a procedure involving general anesthesia while taking GLP-1 drugs.

Due to the digestive-slowing effects of these medications, it may be necessary to discontinue use several days prior to the procedure to ensure an empty stomach before the administration of anesthesia.

Cost

The typical cost for GLP-1 oral medication is approximately $200 to $300 per month at the standard dosage. Prices for medication can fluctuate depending on the geographical location and the specific compound pharmacy being utilized.

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